Selected References These references are in PubMed. This may not be the complete list of references from this article. Zinman B. The physiologic replacement of insulin.

Author:Goltizilkree Bagami
Language:English (Spanish)
Published (Last):4 September 2007
PDF File Size:16.96 Mb
ePub File Size:4.36 Mb
Price:Free* [*Free Regsitration Required]

Selected References These references are in PubMed. This may not be the complete list of references from this article. Zinman B. The physiologic replacement of insulin. An elusive goal. N Engl J Med. Intensive insulin therapy for treatment of type I diabetes. Diabetes Care. Modern management of insulin-dependent diabetes mellitus. Med Clin North Am. Regulation of carbohydrate metabolism and response to hypoglycemia. Endocrinol Metab Clin North Am.

Insulin gene structure and function: a review of studies using recombinant DNA methodology. The physiological basis of insulin treatment--clinical aspects.

Products of therapeutic insulins in the blood of insulin-dependent type I diabetic patients. The insulin receptor. A multifunctional protein. Understanding insulin: the old and new. Adv Intern Med. Receptor binding properties and biologic activity in vitro of biosynthetic human insulin.

Comparison of the activity and pharmacokinetics of porcine insulin and human insulin Novo as assessed by the glucose clamp technique in normal and diabetic man. A fifteen-month double-blind cross-over study of the efficacy and antigenicity of human and pork insulins. Diabet Med. Human insulin and porcine insulin in the treatment of diabetic children: comparison of metabolic control and insulin antibody production. Human and porcine regular insulins are equally effective in subcutaneous replacement therapy.

Results of a double-blind crossover study in type I diabetic patients with continuous subcutaneous insulin infusion. Hypoglycaemia and human insulin. Human insulin--medical progress? Hormonal counterregulatory responses to human semi-synthetic and recombinant DNA and porcine insulin induced hypoglycaemia.

Diabetes Res. Absorption kinetics and action profiles of intermediate acting human insulins. Factors influencing the absorption, serum insulin concentration, and blood glucose responses after injections of regular insulin and various insulin mixtures. Treatment of diabetic coma with continuous low-dose infusion of insulin. Br Med J. Treatment of diabetic coma with small intravenous insulin boluses.

Diabetic crises in children treated with small doses of intramuscular insulin. Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site. Control of blood sugar in insulin-dependent diabetes: comparison of an artificial endocrine pancreas, continuous subcutaneous insulin infusion, and intensified conventional insulin therapy. Absorption kinetics and action profiles of mixtures of short- and intermediate-acting insulins. Mixing short and intermediate acting insulins in the syringe: effect on postprandial blood glucose concentrations in type I diabetics.

Absorption kinetics and biologic effects of subcutaneously injected insulin preparations. Comparison of blood glucose profile and glycemic control in type 1 diabetic patients treated with Actrapid-Monotard or Actrapid Protaphane NPH human insulins. Stability and reproducibility of the biologic activity of premixed short-acting and intermediate-acting insulins. Am J Med. Adsorption of insulin by infusion materials.

Acta Anaesthesiol Scand. Relationship between subcutaneous blood flow and absorption of lente type insulin. Insulin absorption and subcutaneous blood flow in normal subjects during insulin-induced hypoglycemia. J Clin Endocrinol Metab. Smoking reduces insulin absorption from subcutaneous tissue. Rotation of the anatomic regions used for insulin injections and day-to-day variability of plasma glucose in type I diabetic subjects.

Prevalence of residual B cell function and its metabolic consequences in Type 1 insulin-dependent diabetes. Insulin antibodies in insulin-dependent diabetics before insulin treatment.

Immunogenicity of recombinant DNA human insulin. Immunogenicity of highly purified bovine insulin: a comparison with conventional bovine and highly purified human insulins.

Immunogenicity of monocomponent human and porcine insulin in newly diagnosed type 1 insulin-dependent diabetic children. Circulating IgG antibody to protamine in patients treated with protamine-insulins.

Insulin antibody determination: theoretical and practical considerations. The metabolic and hormonal response to acute normoglycaemia in type 1 insulin-dependent diabetes: studies with a glucose controlled insulin infusion system artificial endocrine pancreas. Effect of insulin antibodies and their kinetic characteristics on plasma free insulin dynamics in patients with diabetes mellitus.

Abnormal glucose counterregulation after subcutaneous insulin in insulin-dependent diabetes mellitus. Influence of insulin antibodies on pharmacokinetics and bioavailability of recombinant human and highly purified beef insulins in insulin dependent diabetics. Prolonged action of regular insulin in diabetic patients: lack of relationship to circulating insulin antibodies.

Transplacental passage of insulin in pregnant women with insulin-dependent diabetes mellitus. Its role in fetal macrosomia. Insulin antibodies in diabetic children treated with monocomponent porcine insulin from the onset: relationship to B-cell function and partial remission.

Insulin autoantibodies are associated with islet cell antibodies; their relation to insulin antibodies and B-cell function in diabetic children. Anti-insulin-antibodies and late diabetic complications. Acta Endocrinol Copenh Oct;83 2 — Immunohistopathology of diabetic glomerulosclerosis. Medicine Baltimore Mar;— Insulin antibodies prevent insulin-receptor interactions. Evaluation and management of insulin allergy.

J Allergy Clin Immunol. J Clin Invest. Change of insulin dosage, circulating free and bound insulin and insulin antibodies on transferring diabetics from conventional to highly purified porcine insulin. Circadian profiles of insulin receptors in insulin-dependent diabetics in usual and poor metabolic control.

Am J Physiol. The insulin receptor in insulin-dependent diabetes mellitus: an in vivo and in vitro study. Prandial insulin requirements in insulin-dependent diabetics: effects of size, time of day, and sequence of meals.

Timing of pre-breakfast insulin injection and postprandial metabolic control in diabetic children. Treatment of insulin lipoatrophy with monocomponent insulin. Effects of enhanced conventional therapy on metabolic control in children with insulin-dependent diabetes mellitus.

Hypoglycaemic reactions in Type 1 insulin-dependent diabetic patients. Insulin-induced hypoglycaemia in an accident and emergency department: the tip of an iceberg? Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus. Management of diabetes mellitus in children younger than 5 years of age. Am J Dis Child. Severe hypoglycemia in children with insulin-dependent diabetes mellitus: frequency and predisposing factors.

J Pediatr. Pathogenesis of the dawn phenomenon in patients with insulin-dependent diabetes mellitus. Accelerated glucose production and impaired glucose utilization due to nocturnal surges in growth hormone secretion. Glucose counterregulation and waning of insulin in the Somogyi phenomenon posthypoglycemic hyperglycemia.

Relationship of nocturnal hypoglycemia to daytime glycemia in IDDM. Devices for insulin administration. Glucose control and the renal and retinal complications of insulin-dependent diabetes. Current approaches to continuous insulin replacement for insulin-dependent diabetes: pancreas transplantation and pumps. Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus.


Diabète de type 1



Diabète insulinodépendant (traitement)


Related Articles