IRF450 PDF

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In B cells, IRF4 is highly expressed in mature plasma cells and plays a crucial role in their differentiation. IRF4 has been shown to interact with PU. This transcription factor is upregulated upon T cell activation and is expressed in mature T cells. IRF4 has also been demonstrated to be involved in macrophage polarization and regulation. Lastly, in addition to its roles in normal immune function, IRF4 expression has been reported to be upregulated in many blood-related cancers.

Applications Reported: This 3E4 antibody has been reported for use in intracellular staining followed by flow cytometric analysis. This can be used at less than or equal to 0. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Please make sure that your instrument is capable of detecting this fluorochome.

Excitation: nm; Emission: nm; Laser: Violet Laser. Filtration: 0. Target Information The IRF interferon regulatory factor family of transcription factors are characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes.

IRF4 is lymphocyte specific and negatively regulates toll-like-receptor TLR signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t 6;14 p25;q32 , may be a cause of multiple myeloma.

Alternatively spliced transcript variants have been found. For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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